Hba1c and breast cancer

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Added: 04.02.2021
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Impaired glucose metabolism and hyperinsulinemia have been hypothesized to increase breast cancer risk. However, findings from observational studies relating blood concentrations of hyperinsulinemia markers to breast cancer risk have been inconsistent. We prospectively evaluated whether hemoglobin A1c HbA1c concentrations predict breast cancer risk in a large female cohort. We included 27, female participants of the Women's Health Study who were, at baseline, free of cancer and had usable blood specimens as well as sufficient information on potential risk factors for breast cancer. All Ps were two sided.
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Tamoxifen Associated with Increased Diabetes Risk in Breast Cancer Survivors

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Prolonged Nightly Fasting and Breast Cancer Risk: Findings from NHANES ()

Background: Metabolic acidosis promotes cancer metastasis. No prospective studies have examined the association between dietary acid load and breast cancer recurrence among breast cancer survivors, who are susceptible to metabolic acidosis. Hyperglycemia promotes cancer progression and acid formation; however, researchers have not examined whether hyperglycemia can modify the association between dietary acid load and breast cancer recurrence. Methods: We studied early-stage breast cancer survivors enrolled in the Women's Healthy Eating and Living study who provided dietary information through h recalls at baseline and during follow-up and had measurements of hemoglobin A1c HbA1c at baseline. We assessed dietary acid load using two common dietary acid load scores, potential renal acid load PRAL score and net endogenous acid production NEAP score. Results: After an average of 7.
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Metformin and breast and gynecological cancer risk among women with diabetes

Some types of breast cancer are affected by hormones, like estrogen and progesterone. The breast cancer cells have receptors proteins that attach to estrogen and progesterone, which helps them grow. Treatments that stop these hormones from attaching to these receptors are called hormone or endocrine therapy. Hormone therapy can reach cancer cells almost anywhere in the body and not just in the breast.
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We investigated if metformin lowers breast, endometrial, and ovarian cancer risk in women with type 2 diabetes mellitus compared with women who used other antidiabetic medications. We examined breast, endometrial, and ovarian cancer risk, and the composite cancer risk. We examined drug categories using pharmacy records: metformin only; metformin combination regimens; non-metformin regimens; and non-users. We conducted multivariable Cox regression models with time-dependent drug use status. Given the small numbers of ovarian and endometrial cancer outcomes, we examined these as a composite.
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